About VYJUVEK
VYJUVEK is the FIRST AND ONLY treatment that addresses the GENETIC CAUSE OF DEB to provide POWERFUL WOUND HEALING in a topical gel1
VYJUVEK is indicated for the treatment of wounds in patients 6 months and older with dystrophic epidermolysis bullosa (DEB) with the COL7A1 gene mutation.1Mechanism of Action
Topical COL7A1 gene delivery
In DEB, the mutated COL7A1 gene leads to reduced or absent collagen VII, causing insufficient formation of anchoring fibrils and resulting in fragile skin1
VYJUVEK delivers 2 functional copies of the COL7A1 gene directly into keratinocyte and fibroblast cells of open wounds2
Anchoring fibril production
The functional genes allow the body to produce type VII collagen protein, which is used to create and assemble anchoring fibrils1
Promotion of wound healing
Anchoring fibrils help bind the epidermis and dermis together to promote wound closure1